Harry Potter and the recessive allele
Jeffrey M. Craig1,3, Renee Dow2 and MaryAnne Aitken2,3
1. Chromosome Research, Murdoch Childrens Research Institute, Royal
Childrens Hospital, Flemington Road, Parkville, Victoria 3052,
Australia
2. Genetics Education, Murdoch Childrens Research Institute, Royal
Childrens Hospital, Flemington Road, Parkville, Victoria 3052,
Australia
3. Department of Paediatrics, University of Melbourne, Royal
Childrens Hospital, Flemington Road, Parkville, Victoria 3052,
Australia
Sir:
We are bombarded with news of genetic discoveries on an almost
daily basis, but people without a formal knowledge of heredity and
genetics can have difficulty in deciphering and applying this
information. Education and debate across all ages would undoubtedly
help, but how can we teach children these concepts?
We believe that successful lessons for younger children can be
achieved using analogies of direct interest and relevance. Most
children are familiar with J. K. Rowling's stories about the young
wizard Harry Potter (whose latest exploit, Harry Potter and the
Half-Blood Prince, was published by Bloomsbury in July). They are
set in a world like our own, but populated by a minority of people
with supernatural powers (wizards and witches) and a majority of
people without (muggles).
Wizards or witches can be of any race, and may be the offspring of
a wizard and a witch, the offspring of two muggles ('muggle-born'),
or of mixed ancestry ('half-blood').
This suggests that wizarding ability is inherited in a mendelian
fashion, with the wizard allele (W) being recessive to the muggle
allele (M). According to this hypothesis, all wizards and witches
therefore have two copies of the wizard allele (WW). Harry's
friends Ron Weasley and Neville Longbottom and his arch-enemy Draco
Malfoy are 'pure-blood' wizards: WW with WW ancestors for
generations back. Harry's friend Hermione is a powerful muggle-born
witch (WW with WM parents). Their classmate Seamus is a half-blood
wizard, the son of a witch and a muggle (WW with one WW and one WM
parent). Harry (WW with WW parents) is not considered a pure-blood,
as his mother was muggle-born.
There may even be examples of incomplete penetrance (Neville has
poor wizarding skills) and possible mutations or questionable
paternity: Filch, the caretaker, is a 'squib', someone born into a
wizarding family but with no wizarding powers of their own.
We believe that, with the use of these examples, the concepts of
mendelian genetics can be introduced to children as young as five,
and then built on by gradually introducing specific terms such as
'gene' and 'allele', and relating these to chromosomes and DNA. At
every stage, the children's familiarity with the Harry Potter
characters can be used as a hook to engage them in discussing
concepts of heredity and genetics. -
http://www.nature.com/nature/journal/v436/n7052/full/436776a.html