for a maniac like me, i usually drain it and then remove the
skin.. then use iodine to burn it shut...
but that's me.. normal people will probably pass out from the
pain...
do NOT break the skin...
try to protect it with padding and plasters..
in the future, if you have new shoes, wear it for a few minutes,
then figure out where will cause blisters, use a candle to smooth
out the part of the shoe, and/or use masking tape on that part of
the foot so that the shoe does not rub the skin raw 
