It's known as the HPAC pathway...
hypothalamus - pituitary - adrenocorticoids pathway...
Yeah... it's proven to reduce the heart rate, the venous return,
the respiratory rate, the pulse rate and the cardiac output, hence
slowing blood flow to the carotids and hence the brain, reducing
the neurochemicals and leading to severe and exacerbation of
depression... oh too bad... 
