Comodo Antivirus and Firewall.
Pick the combo install package if you want to run both
(some people install only the AV or the FW and realise they can
only run one at a time if they download and install the wrong
package)
Its free. Lightweight on system resources.
Geekspeak:
Comodo creates 'sandboxes' of all running programs and alerts
you if fishy stuff happens to your registry. Sandboxes are
controlled environments where you can run programs and are unsure
of their impact to your system. If anything happens it doesn't
spillover to your system and the sandbox can be destroyed
anytime.
Sandboxing is excellent for people who torrent random fishy
files online and are unsure of their impact. Or who know what
they're doing and want extra protection. This is for you.
They also have secure DNSing for those of you who know enough
about DNSes and know how to optimize that.
# would love if comodo had a corporate client available. it
detects stuff slipping through even corporate
anti-viruses/anti-malware. An excellent safety net, even as a
secondary AV program.