There should not be much difference in the speed though,
although you can say thaE4500 is an older processor that's out
before theE4600.
The price difference is about $50, which i dont think, should be
spent, if you have a $500 - $600 upgrading budget.
for $50 you could get a 1gb ram for your desktop.
but before you get the processor, you must first see if your
motherboard is suitable to use this processor anot, if not you buy
for what?