Systemic lupus erythematosus
(SLE or lupus, pronounced
/sɪˈstɛmɪk
ˈluːpəs ˌɛrəˌθiməˈtoʊsəs/) is a chronic autoimmune disease
that can be fatal; however, with recent medical advances,
fatalities are becoming increasingly rare. As with other autoimmune
diseases, the immune system
attacks the body’s cells and tissue, resulting in inflammation and
tissue damage. SLE can affect any part of the body, but most often
harms the heart, joints,
skin, lungs,
blood vessels,
liver, kidneys, and nervous
system. The course of the disease is unpredictable, with
periods of illness (called flares) alternating with remissions.
Lupus can occur at any age, and is most common in women,
particularly of non-European descent.[1]
Lupus is treatable through
addressing its symptoms, mainly with corticosteroids
and immunosuppressants;
however there is currently no cure. Survival in patients with SLE
in the United States, Canada, and Europe is approximately 95% at 5
years, 90% at 10 years, and 78% at 20 years.[2
