You have to go PGP first, then walk to the bus stop to take that
shuttle, so a bit no point, unless you lodge in PGP.
(There is a 'shortcut' to take the shuttle, but you must be very
lucky. You can take the Science Park - NUS shuttle (the minibus),
get off at Science Park II, then take the shuttle (which comes at
fixed timing) to Harbour Front.)
From NUS, there are a few ways to travel to Harbour Front.
1. 97 at the AYE bus stop.
2. 10 at Kent Ridge Terminal
3. 10/30/143/188 at Heng Mui Keng Bus Stop outside Biz.